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Reported adverse effects of IV glutathione include adverse cutaneous eruptions including potentially fatal Stevens-Johnson syndrome and toxic epidermal necrolysis, severe abdominal pain, thyroid dysfunction, renal dysfunction, and lethal complications such as air embolism or potentially fatal sepsis due to incorrect/unsterile method of IV administration, with side effects on the use of injectable glutathione for skin lightening including toxic effects on the liver, kidneys, and nervous system

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Outside the GLP-1 class, other segments showed less robust growth