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All of the variables listed in Table 1 were included in the calculation of propensity score, except for the follow-up year which was replaced with the index date

Studies have shown that GLP-1 receptor agonists like semaglutide can decrease inflammatory cytokines and improve overall inflammatory status, which may contribute to longevity and healthspan benefits

Regulatory acceptance varies by region, with formal approval in certain therapeutic settings and off-label use prevalent in others under clinical supervision

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