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Gentle swirling is typically sufficient to achieve full dissolution within a short window, and a solution that remains cloudy or shows visible particulates after adequate swirling time is generally a sign that something in the process the solvent choice, the technique, or the compound itself needs a second look

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A Multicenter, Randomized, Double Blind, Placebo Controlled Phase II Study of PL 14736 Enema in the Treatment of Mild-To-Moderate Ulcerative Colitis, Ulcerative Colitis Study Group

This is common in conditions like pernicious anemia, Crohn's disease, or after certain stomach surgeries