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Additionally, both hypothyroidism and GLP-1 receptor agonists can affect gastrointestinal motility

People with a resting heart rate already above 100 beats per minute, or with conditions like hypertrophic cardiomyopathy or unstable arrhythmias, need careful evaluation before considering retatrutide

Paediatr Child Health 27(1):5055 Esrick EB, Lehmann LE, Biffi A, Achebe M, Brendel C, Ciuculescu MF, Daley H, MacKinnon B, Morris E, Federico A, Abriss D, Boardman K, Khelladi R, Shaw K, Negre H, Negre O, Nikiforow S, Ritz J, Pai SY, London WB, Dansereau C, Heeney MM, Armant M, Manis JP, Williams DA (2021) Post-transcriptional genetic silencing of BCL11A to treat sickle cell disease

When patients show low GLP-1 persistence or discontinue their medications early, they dont achieve the weight loss needed to reduce their risk for cardiometabolic diseases, and payers face wasted spend and insufficient ROI