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Inflammation Systemic chronic inflammatory response characterized by altered cytokine production and the activations of inflammatory signaling pathways is being actively investigated to determine its role in obesity-related insulin resistance [145]

Relevant role of neutrophils in oxidative stress

Drach J, Lopez-Berestein G, McQueen T, Andreeff M , Mehta K

A recent study demonstrated that NLRP3/caspase-1/GSDMD-mediated pyroptosis in fibroblasts is relatively limited compared with that in macrophages, which express high levels of NLRP3, caspase-1 p20 and GSDMD-NT under LPS plus ATP stress, a strong NLRP3 inflammasome activator and pyroptotic trigger