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J Lipid Res 52:16931701 Xu C, Bai B, Fan P et al (2013) Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice

Moreover, the lack of cardiovascular benefits observed with lixisenatide may be contributed to its relatively short half-life [78]

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GIP and glucagon receptor activation may contribute through effects on nutrient sensing and metabolic fuel availability