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( Epub 2019/09/14 )

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8.1 Key scientific findings 8.1.1 Molecular mechanisms of EED-induced reproductive toxicity The mechanistic foundation of EED reproductive toxicity involves systematic disruption of fundamental cellular processes

Potential causes include pre-existing vascular ED that was present before tirzepatide but was attributed to the medication, medication interactions with drugs known to cause ED (SSRIs, beta-blockers, spironolactone, finasteride), severe nutritional deficiencies from inadequate intake, or undiagnosed conditions like depression or hypogonadism unrelated to obesity