For further prognostic evaluation and clinical decision-making, breast cancer can be classified into three subgroups based on immunohistochemical staining results for ER, PR, and HER2: HR-positive/HER2negative (HR+/HER2, ~70%), HER2positive (HER2+, ~1520%), and triple-negative breast cancer [TNBC, HR-negative (HR-), HER2, ~15%]
Another effective way to enhance glutathione levels is through lifestyle modifications
Fluoroquinolone exposure tends to suppress the TCA cycle and activate the glyoxylate shunt, conserving carbon and reducing ROS while channeling electrons into NADPH/GSH synthesis
Li T, Xu H (2020) Selenium-containing nanomaterials for cancer treatment