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Thus, TfR2 would enable the rapid and specific hepatic clearance of toxic heme from plasma by HPX in a variety of clinical hemolytic conditions, where iron homeostasis at both cellular and systemic levels is in flux

Ponnanikajamideen M, Rukumani V, Paulkumar K, Vanaja M, Rajendran RS, Annadurai G

Immunohistochemistry analysis indicated that chemotherapy-resistant patients had significantly higher expression levels of NRF2, GPX4 and SOD1 in tumor tissues compared to the sensitive ones