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These direct effects are further supported by human studies demonstrating the wide expression of GLP-1 receptors in the proximal tubules, juxtaglomerular cells, hilar and intralobular arteries, and preglomerular vascular smooth muscle cells [49]

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The reaction formula can be summarized as follows: 2 GSH GSSG + 2H + 2e (under the action of GPX or ROS) However, to prevent GSSG accumulation from disrupting the intracellular sulfhydryl balance, cells need to rapidly convert it back to GSH through an efficient reduction system