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Unlike fat-soluble vitamins that accumulate in body tissues, water-soluble vitamins are generally excreted through urine when consumed in excess

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The strong preclinical muscle findings such as IGF-1 overexpression preventing age-related muscle loss in mice used locally expressed native IGF-1 isoforms in animals, not systemically injected IGF-1 LR3 in people

10.1111/j.1440-1754.1982.tb01978.x Aust Paediatr J