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This multifactorial approach resulted in the manifestation of typical clinical HFpEF features, including ventricular hypertrophy, increased collagen deposition and fibrosis, elevated blood pressure, and diastolic dysfunction

A complete clinical picture requires accounting for the other hormones whose decline shapes how both therapies perform in practice, and in some cases, how effectively they protect the very systems this section has been examining

V., & Contel, M