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Altogether, these findings enhance our understanding of the molecular basis for acyl-ghrelin recognition and activation of the ghrelin receptor and provide a framework for the drug design targeting the ghrelin receptor

Approaches such as intrathecal, intracerebroventricular, and intraparenchymal injections, as well as transient BBB disruption, have been employed to deliver drugs with limited CNS bioavailability (Ganger and Schindowski, 2018