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"L-carnitine exerts a nutrigenomic effect via direct modulation of nuclear receptor signaling in adipocytes, hepatocytes and SKMC, demonstrating its nutritional impact." Nutrition Research , January 2021, Jeukendrup, A E et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Schwenk W.F., Hale D.E., Haymond M.W

Moreover, both HFD and caloric restriction stimulate peroxisome proliferator-activated receptors (PPAR)- and associated pathways, which produce acetyl-CoAs essential for ketogenesis and supply substrates for energy metabolism, hence supporting intestinal development

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