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Pros: Much cheaper ($40$120 per 5mg vial, translating to $150$500/month depending on dose), no prescription required, widely available Cons: No quality control, contamination risk, no medical oversight, legal ambiguity, no recourse if something goes wrong Risk mitigation: Third-party testing through labs like Janoshik, vetting vendors through Reddit and peptide forums, starting with small test orders Grey Market Risks Research peptides are not FDA-regulated

GLP-1 receptors are also expressed in blood vessels, suggesting effects on vascular function and circulation

Nausea, constipation, and reflux are common, especially during dose escalation, and going slower or staying lower feels like the obvious fix

The evidence is for FDA-approved branded formulations