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[4] In the SURMOUNT-1 obesity trial, a 72-week placebo-controlled study in 2,539 adults with obesity (without diabetes), mean weight change was 15.0%, 19.5%, and 20.9% at the 5, 10, and 15 mg doses versus 3.1% for placebo

This is a paradigm shift in thinking: metformin alone is no longer the automatic sole choice as first-line therapy in type 2 diabetes

McCarty, a gastroenterologist and researcher at Houston Methodist who led the study

Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial