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Mono- and combination therapies differentially enhance beta cell identity and attenuate beta cell stress and immunogenicity To elucidate the molecular mechanisms underlying beta cell protection by mono- and combination therapies, we performed spatial transcriptomic profiling of pancreatic sections from 12- and 17-week-old untreated mice, as well as from mice 5 weeks after receiving aCD3 monotherapy, GLP1-E2 monotherapy or aCD3+GLP1-E2 combination therapy

However, dizziness may occur, particularly while the dose is being increased

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However, post-market surveillance and patient forums document musculoskeletal discomfort emerging during active weight loss phases