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Normal saline (0.9% NaCl) is sometimes mentioned as an alternative

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To address this problem, the use of ozone to prepare chitosan reduces the use of acetone and NaOCl, and eliminates chemical waste 228

Smoking cigarettes involves a substantial amount of free radicals that may degrade exogenous and endogenous antioxidants, as well as dysregulate monocytes and vascular smooth muscle cells [70] Endothelial nitric oxide synthase (eNOS)- derived nitric oxide plays a crucial role in regulating platelet accumulation, vasodilation, and maintaining stability between smooth muscle cell growth and proliferation