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This mechanism is particularly useful during exercise, especially steady-state cardio where fat becomes the primary energy source

Traditional risk assessment models, such as the American Society of Anesthesiologists (ASA) classification and the Charlson Comorbidity Index (CCI), while valuable, are relatively macroscopic and fail to fully capture the individualized nutritional and inflammatory status of the patient, thus having limited predictive efficacy (23)

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The Federal Register docket number for this proposal is 2026-08552