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There is also a trial specifically testing whether retatrutide prevents heart attacks and strokes (TRIUMPH-3, 1,800 people), and a head-to-head trial comparing retatrutide directly against tirzepatide (the active ingredient in Zepbound) under identical conditions (NCT06662383, 800 patients)

There is also the very real possibility there will be continual churn among GLP-1 users, as people cycle on and off the drugs throughout their lifetime