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reported a decreased mucus thickness in the colon of cirrhotic patients and a breakdown of E-cadherin and occludin by endogenous and newly identified bacterial proteases respectively, which could be future therapeutic targets (151)
superoxide anion (O2), singlet oxygen radical (1O2), peroxyl radical (ROO), nitric oxide radical (NO) and lipid peroxy radical (LOO) as well as peroxynitrate (ONOO), trichloromethane (CHCl3) and hypochlorous acid (HOCl) which are not necessarily free radicals but have high tendency to generate free radicals
It breaks down damaged, disorganized collagen and replaces it with new, properly structured fibers
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