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Pillar 1: Activity (aerobic + resistance + daily movement) Physical activity improves insulin sensitivity through several mechanisms at once: increased glucose uptake (including non-insulin-mediated uptake), improved muscle insulin signalling, reduced intramuscular lipid burden (DAGs), improved hepatic insulin sensitivity, and improved appetite regulation via brain signalling

For people with the genetic hair loss conditions Male Pattern Baldness and, the women's equivalent, Female Pattern Hair Loss , this could be extremely interesting as the incidence of both conditions increases with age

In small cell lung cancer (SCLC) patients, genetic variations in glutathione metabolism and DNA repair pathway genes have been significantly associated with survival

When activated, it doesn't just signal the brain to stop eating but starts a cellular clean up process by changing how genes related to insulin sensitivity and lipid metabolism are transcribed