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[18] Ongoing communication with healthcare providers should include reporting of side effects such as persistent nausea, vomiting, diarrhea, abdominal pain, or signs of dehydration

Thomas L, Eckhardt M, Langkopf E et al (2008) (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors

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Both options have minimal interaction risk with semaglutide and can be used regularly without building tolerance