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PMID: 5 BurkeSJBatdorfHMEderAEKarlstadMDBurkDHNolandRCet al

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In 2010, liraglutide97% homologous to human GLP-1was approved first for diabetes and later for obesity in 2014, while semaglutide, also a modified GLP-1 analogue, now treats both conditions 5

Scientists found that GLP-1 receptor mRNA levels in the nucleus tractus solitarius (NTS) dropped after 1-2 weeks of treatment, matching when the drug started becoming less effective [24]