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Signs of low glutathione are how some of those battles start to show on the outside: the fatigue that a weekend off doesn't fix, the skin that looks tired even after eight hours in bed, the cold that just won't leave

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Recent work using single nuclear RNA sequencing and translating ribosome affinity purification sequencing showed that mHtt mediates the release of mitochondrial RNA which then binds to the innate immune sensor protein kinase R, resulting in the activation of innate immune signaling in the most vulnerable HD neurons: spiny projection neurons (Lee et al., 2020)