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Previous research has shown that SLC3A1 is highly upregulated in various breast cancer cell lines compared with the upregulation of the light chains SLC7A5, SLC7A7 and SLC7A9 (49)

HSP90 inhibitors such as ganetespib (STA-9090) and AUY922 have been extensively evaluated in oncology, 54,55 where they disrupt the stabilization of oncogenic client proteins

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