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This triple-mechanism approach provides longer-lasting intracellular antioxidant protection compared with standalone glutathione supplements

10.1007/s00726-022-03175-z 6 BeheraL

Importantly, either genetic silencing of NCOA4 or treatment with the iron chelator deferoxamine (DFO) significantly attenuated these pathological changes, resulting in over 60% improvement in neuronal survival (Plascencia-Villa and Perry, 2021)

Since vitamin B12 is found in many foods, deficiency is more common in the elderly, strict vegetarians, or those who take oral contraceptives or medications for gastric disorders or insulin resistance