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In the context of the GHK-Cu pathway, which supports tissue regeneration, collagen production, and anti-inflammatory signaling, elevated TNF activity may counteract some of the regenerative benefits by promoting ongoing inflammatory stress within tissues

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The addition of semaglutide to this already high-risk group showed further b12 decline, but whether this represents a medication effect, dietary changes from additional appetite suppression, or natural progression of post-surgical deficiency remains unclear