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Clinicians who recognize the symptom pattern of undiagnosed hypothyroidism, particularly swelling of the small joints of the hands and feet, fatigue, cold intolerance, and carpal tunnel without a mechanical explanation, provide real value to their patients

Downstream DAMP-associated microglia activation results in the assembly of the classical NADPH oxidase on the plasma membrane, resulting in the release of superoxides into the extracellular space, where they contribute to neuronal damage (Della Bianca et al., 1999)

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A multivitamin may be useful as a safety net but its no substitute for a nutrient-rich diet