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The continued treatment with 1 M was done as this concentration is within range of the serum concentrations of the sum of tamoxifen and its metabolites in breast cancer patients treated with tamoxifen [24]

J Endocrinol (2002) 173:7380

doi: 10.1016/j.lfs.2018.10.045 61 MhlerH

Among 17,604 participants with established cardiovascular disease and overweight or obesity but without diabetes, the primary event hazard ratio was 0.80 (95% CI 0.72-0.90) over a mean 39.8-month follow-up