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Kristin Jacob offered another modified interpretation of the EPIC Study report, using the term "significant" to describe the necessary degree of enlargement (distinguishing it from "mildly enlarged"), when she wrote: "The data from this landmark study supports the use of Pimobendan once signs of significant left atrial and left ventricular dilation are present but not when the heart size is normal or even mildly enlarged ." (Emphasis added.) It would have been more helpful if these cardiologists quantified "substantial" or "significant" enlargement

doi: 10.3390/MOLECULES30071470 126 GiampaoliOContaGCalvaniRMiccheliA

Frontiers in Physiology, 12 , 700352

Maintaining sterile technique is essential when working with bacteriostatic water