189,190,191 Originally identified as essential regulators of pluripotency in ES cells, they have been shown to maintain stem-like properties in various cancer types
10.1667/RR3255.1 209 Sadegh MalvajerdS.AzadiA.IzadiZ.KurdM.DaraT.DibaeiM.et al (2019)
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A cachexia trial was prematurely terminated due to a cardiac risk signal in some vulnerable subgroups