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In studies, kidney-specific ANGPTL4-ASO-treated mice exhibited partially restored kidney structure, substantially reduced glomerular and cortical fibrosis, and decreased proteinuria, without changes in body weight, blood glucose, or blood pressure in diabetic mice

[16] [17] Any suspected side effects from hydroxocobalamin injections should be reported via the MHRA Yellow Card scheme (available at yellowcard.mhra.gov.uk)

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Immunofluorescence staining was performed to assess macrophage polarization, with CD86 serving as a marker for pro-inflammatory M1 macrophages and CD206 for anti-inflammatory M2 macrophages