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Additionally, immune-related pathways were activated in the long term, with a short-term upregulation of inflammatory markers, such as interleukin ( IL)-6 and IL-18 , although the levels of matrix metalloproteinases (MMPs) remained stable, indicating that not only complex inflammatory stimuli, but also oxidative stress responses can disrupt ECM homeostasis

Food changes occurred daily at 8.00 am

It acts as a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis, influencing the release of key hormones such as luteinizing hormone and supporting natural testosterone and estrogen signaling

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