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Comparable to therapy with GLP-1RA, a stepwise dose escalation starting with a low starting dose was associated with a lower rate of gastrointestinal side effects and better tolerability of tirzepatide (67)

These chemical groups affect a hormones distribution, the type of receptors it binds to, and other aspects of its function

Increasing the half-life of peptides is possible by preventing their degradation by blood proteases through blocking the C- and N-termini of peptides or forming cyclically shaped peptides [29]

The results were compared with the wild type BRAF sequence (NM_001354609.2)