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Children at this young age are able to metabolize acetaminophen and to detoxify NAPQI more efficiently due to their greater hepatic mass (comparing organ weight to total body weight)

In that study, ALFF, an rs-fMRI metric indexing the amplitude of spontaneous low-frequency BOLD oscillations, was used as a proxy of regional intrinsic activity rather than a direct measure of synaptic plasticity 57,58

The pharmacokinetic behavior of BYDUREON BCISE is expected to be consistent with that of BYDUREON in adolescent patients

However, this effect is not dose-dependent, and the highest values were reached with 50 ng/mL on day 3 after IGF-1 administration (Raghavan et al., 2012)