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551 Moreover, inability to selectively target the diseased cells and off-target toxicity are the areas of particular concern, leading to the surge for more consistent alternatives

In contrast to liraglutide ( These data suggest that rodents are particularly sensitive to the effects of GLP-1 agonists on thyroid C cells but these foindings could not be considered as predictive of an increased risk of thyroid C-cell tumors in patients under GLP-1 receptor agonist therapy ( Insulin Insulin is a widely prescribed glucose-lowering agent (Sims et al., 2021) especially in patients affected by type 1 diabetes mellitus (T1DM) as well as in some patients with Type 2 diabetes mellitus

Patients with diabetic macular edema, severe or proliferative diabetic retinopathy, as well as those with a history of prior retinal surgeries were excluded

A recent meta-analysis highlighted that females generally achieve greater weight loss than males when treated with GLP-1 RAs [55]