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It is believed to influence levels of dopamine, norepinephrine, and serotonin in the brain key neurotransmitters involved in satiety, mood, and metabolism
Ancillary and post-trial care Post-trial care of the participants will include treatment with metformin in line with the latest international guidelines that advise a consideration of metformin as an adjunct to lifestyle intervention in adult women with PCOS with body mass index (BMI) 25 kg/m 2 , regardless of the presence of glucose disturbances and menstrual irregularity, for the management of weight and preventing or slowing progression to adverse cardiometabolic outcomes [21]
Weight loss often occurs, but it is considered a secondary benefit , not the primary treatment goal
Regul Peptides (1995) 58:149156
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