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A large systemic review of cardiovascular outcomes of people taking GLP-1 agonists significantly reduces death from cardiovascular causes by 12% and stroke by 16%

"The debate around GLP-1 coverage is a prime example of the balancing act benefits leaders face as they navigate skyrocketing demand, affordability concerns, and uncertainty around long-term patient outcomes." Analysts note payers are progressively weighing partially or fully unbundling pharmacy benefit manager (PBM) services to maintain costs and increase transparency, with 60% of health plans and 51% of employers reporting they would consider a partially or fully unbundled model

Combining or overlapping weight-loss injections may increase uncertainty and adverse-effect risk