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After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10

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The method was qualified for the quantification range of 11000 ng/mL with accuracy and precision of 20%, except for at the lower limit of quantification when the accuracy and precision were 25%

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