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Surrogates are not outcomes

In preclinical and in vitro systems, IGF-1 LR3 is commonly used to explore mechanisms of cell proliferation and differentiation, myostatin-related signaling in muscle biology, and metabolic processes involving glucose handling and lipid mobilization

It comprises a complex network of different organs, cells, proteins, tissues and chemical substances that have the function of maintaining the body's own structure by defending against foreign substances and pathogens such as bacteria, viruses, parasites or fungi

Nishida Y, Scruggs DA, Ayoub E, Ostermann LB, Patsilevas T, Ruvolo VR, Mak PY, Carter BZ, Boettcher S, Maiti A, Sasaki K, Zhou Q, Yang Z, Yan H, Ma L, Andreeff M