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Deletion of IGF1R in MSCs results in decreased bone mass but does not affect growth To explore the role of IGF-1 signaling in MSC fate and bone formation postnatally, we crossed the Nestin-Cre ER mouse with Igf1r fl/fl mice to generate the desired genotypes (Figure 2)

These studies may use weight-matched comparisons or look at biomarker responses in people without diabetes

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