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However, in certain cases evidence exists of selection at the somatic cell level after X-chromosome inactivation

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Janus kinase3 (JAK3) is expressed in erythrocytes, phosphorylated upon energy depletion, and involved in regulating eryptosis by triggering cell membrane scrambling (Bhavsar et al., 2011)

This matters especially when using glutathione or other pigment suppressors, to reduce the risk of rebound hyperpigmentation