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dynamic PDU is considered by dedicated guidelines as the gold standard for the diagnosis of ED of vasculogenic etiology, by allowing to objectively quantify penile vascular status and identify potential vascular abnormalities, before and during an erection, therefore representing the best candidate tool for the purposes of the current study, focused on vasculogenic ED [35, 36]

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While dehydration itself is not typically reported as a direct side effect in clinical trials, the risk stems from the common gastrointestinal side effects that can lead to fluid loss