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If orforglipron can be manufactured at scale for a fraction of the cost of injectable alternatives, and if its oral format eliminates the injection barriers that prevent millions from starting therapy, the public health impact could be measured in reduced cardiovascular events, fewer diabetes-related amputations, decreased obesity-related cancer incidence, and extended healthy lifespan across populations

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In contrast, modern GLP-1 receptor agonists and dual incretin agonists have demonstrated clinically meaningful and sustained reductions in body weight, with additional benefits on glycemic control and cardiometabolic risk markers

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