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Contraindications aren't absolute

Patients with pre-existing gastrointestinal conditions, such as irritable bowel syndrome, may be more susceptible to these symptoms

They have a shorter half-life, and are taken at mealtimes to enhance insulin secretion and prevent postprandial hyperglycemia ("postprandial" means after eating)

Se han identificado GLP-1R en el ndulo sinoauricular, miocitos auriculares y ventriculares y endotelio vascular, cuya activacin genera efectos antiinflamatorios, reductores del estrs oxidativo y antiaterognicos, que sustentan los efectos cardioprotectores y nefroprotectores de los agonistas de GLP-1 (fig