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Additionally, the peptide's proposed anti-inflammatory properties (via modulation of TNF- and IL-6 in adipose tissue) and potential stimulation of chondrocyte metabolism offered biological plausibility for OA treatment

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Fernandes L, Hagen KB, Bijlsma JW, Andreassen O, Christensen P, Conaghan PG, Doherty M, Geenen R, Hammond A, Kjeken I, Lohmander LS, Lund H, Mallen CD, Nava T, Oliver S, Pavelka K, Pitsillidou I, da Silva JA, de la Torre J, Zanoli G, Vliet Vlieland TP (2013) European League Against R EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis

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