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Old age is a factor causing significant changes in pharmacokinetics, mainly at the stage of distribution (increased content of adipose tissue and 1 acid glycoprotein, reduced water content and albumin concentration) and elimination (impaired renal function, slower hepatic metabolism) [153, 366]

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Your starting point, your daily habits, and how you stick to the plan all play a huge role

Probiotics, prebiotics, synbiotics, postbiotics, and obesity: current evidence, controversies, and perspectives