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Moreover, nanoparticle crystals Ali-Rux composed of the Aurora kinase inhibitor alisertib (Ali) and the JAK2 inhibitor ruxolitinib (Rux), can remodel the TME by increasing the recruitment and activation of CD8 + T cells and NK cells while reducing MDSCs, and can trigger a lasting anti-tumor immune response when combined with PD-L1 blockade (193)