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This inverse relationship between body size and lifespan is unique to domestic dogs and is thought to result from accelerated growth rates and higher metabolic demands in large breeds, which may increase oxidative damage and cellular damage [64]

Owing to its unique structure and mode of action, SS-31 demonstrates potential therapeutic value across cardiovascular diseases, neurodegenerative disorders, kidney injury, and myopathies associated with mitochondrial dysfunction 1-6 .

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These channels, such as Piezo1 and Piezo2, respond to mechanical stimuli by allowing ions to flow into cells, triggering downstream signaling pathways that regulate cellular responses to mechanical stress